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Taken together, these observations suggest that except in vitamin B 12 deficiency (which only responds to cyanocobalamin treatment because of the inactivation of methionine synthase), folate treatment should be the most adequate therapy to reverse hyperhomocysteinemia detected both under basal conditions and after an oral methionine load

For example, recent studies showed a relationship between rs12201199 in thiopurine S-methyltransferase gene ( TPMT ) and rs9332377 in the catechol-O-methyltransferase gene ( COMPT ) with cisplatin-induced hearing loss in children (Ross et al., 2009)

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It is imperative to monitor patients for sedation and fall risks associated with these medications (68, 79, 85)