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doi: 10.1038/s41467-023-41860-z 239 TatovicDNarendranPDayanCM

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Protein kinase c-theta mediates a selective T cell survival signal via phosphorylation of BAD

Olsen et al., 2003

Following cellular uptake, cystine undergoes reduction to cysteine, primarily mediated by thioredoxin-related protein 14 (TRP14) through the dithiol-disulfide exchange ( Additionally, L-OOH is oxidized by Fe 2+ to generate tremendously reactive lipid alkoxyl radicals (LO), which destroy PUFAs through a chain reaction, leading to membrane injury and cell death ( 2+ in the unstable iron pool, preventing the formation of hydroxyl radicals from its reaction with H 2 O 2 ( 2.2.3 Lipid metabolism Fatty acids are essential molecular constituents of the brain, comprising over 50% of its dry weight, with PUFAs representing approximately 40% of the total FAs ( Omega-3 PUFAs possess distinct anti-inflammatory and metabolic characteristics, suggesting their significant potential for treating PD and AD (Zou et al., 2020), adversely impacts neural functions by altering membrane potential and disrupting ion homeostasis