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Merck expanded its ophthalmology portfolio by acquiring Eyebiotech Limited for US$ 1.3 billion (plus US$ 1.7 billion in milestone payments), obtaining Restoret for diabetic macular edema and neovascular age-related macular degeneration

Furthermore, ubiquitination and proteasomal degradation of TFR1 counteract abnormal iron accumulation and ferroptosis, mitigating acute liver injury (95)

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Advanced fibrosis has a more significant effect on long-term prognosis than NASH, with approximately 40.8% of NASH patients showing fibrosis progression during follow-up