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Given the established link between TLR4 and NLRP3 (96) as well as evidence from Gaucher Disease models (97), highlighting activation of the inflammasome, with subsequent caspase-1 activation, leads to the maturation of IL-1 in Gaucher macrophages and that inflammasome activation in these cells is the result of impaired autophagy

Recent investigations have pioneered three critical advancements in diabetic peripheral neuropathy (DPN) research: (1) systematic elucidation of ncRNA regulatory mechanisms through exosome-mediated transcellular signaling (eg, miR-146a-5p nanoparticles enhancing nerve repair), (2) integration of multi-omics technologies to decode epigenetic-metabolic networks, and (3) development of nanotherapeutic strategies enabling diagnosis-to-treatment synergy

Wolf AJ, Reyes CN, Liang W, Becker C, Shimada K, Wheeler ML, et al

Effect of watermelon supplementation on exercise performance, muscle oxygenation, and vessel diameter in resistance-trained men

Bone is one of the most common distant target sites for BrCa metastasis