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Singh et al., 2020), enhancing susceptibility to not only LC and CFS but also post viral fatigue syndrome in general, POTS (Blitshteyn, 2017), SIBO, MCAS, EDS, and some MTHFR variants (Okamot et al, 2012)

revealed that legumain deficiency alleviated the development of renal tubular injury and ferroptosis in AKI mice, which proved legumain enhanced renal tubular epithelial cell ferroptosis by facilitating autophagy in AKI( Inflammation During ferroptosis, the shrinkage of cell and organelle membranes and the increase of permeability cause cell content release, including damage-associated molecular pattern (DAMPs) (Mu et al., 2021)

2b and Supplementary Table 2)

Collins, M

The results showed that both RFP-Lc3 + and AO + cells were dramatically increased in the zebrafish midbrains after sulindac treatment (Fig