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Their stability is influenced by several factors, including: Amino Acid Sequence : Certain amino acids, such as cysteine, methionine, tryptophan, and glutamine, are more susceptible to oxidation or degradation

Extending these findings to cellular models, another study showed that visible to near-IR light (150 W tungsten lamp, up to 30 min) induced 8-oxo-dG formation in mouse lymphoma cells and human lung fibroblasts supplemented with riboflavin 174

Smoking also increases risk by reducing blood flow to spinal structures and impairing tissue repair