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w Z, Konopleva M, Shi YX, McQueen T, Harris D, Ling X, Strov Z, Quintas-Cardama A, Samll D, Cortes J, Andreeff

Glutathione, a potent antioxidant, is generally considered safe for topical use and has minimal systemic absorption

Future directions focus on precision medicine, biomarker-guided treatment, and AI-assisted disease monitoring, alongside next-generation therapeutics such as long-acting FcRn inhibitors (IMVT-1402), bispecific antibodies (gefurulimab), and oral small molecules (remibrutinib, iptacopan)

342,343,344 Particularly in ccRCC, low expression of FDX1 is significantly associated with advanced TNM staging, lymph node metastasis, and poorer prognosis

Collagen fibers are thicker and coarser in the inner dermal layer than in the outer layer, with thinner and more tenuous collagen fibers (68)