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This strategy works upon intracellular conversion of a relatively non-toxic prodrug into a toxic drug by a xenobiotic origin enzyme and has been referred to as genetic prodrug activation therapy (GPAT) [45]

Cervical tumors overexpress matrix metalloproteinases (MMP-2, MMP-9), cathepsins, and hyaluronidasesenzymes involved in ECM degradation, invasion, and angiogenesis [203, 204]

Reagan-Shaw S, Nihal M, Ahmad N (2008) Dose translation from animal to human studies revisited

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MDA is an important indicator of lipid peroxidation and oxidative conditions