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For IMR-5/75, the culture media was supplemented with 5 g/mL Blasticidin (Bio-Sciences) and 50 g/mL Zeocin (Thermo Scientific) for plasmid selection

Semaglutide, the latter has a clinically tested dosage

In its complete response letter (CRL), the FDA cited several CMC issues, open observations from pre-approval manufacturing inspections and a lack of substantial evidence, according to Outlook