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These findings provide a comprehensive description of OVX-induced glutathione redox stress at multiple levels and support HPL therapy as an effective modulator in renal tissues to locally influence the glutathione metabolism pathway and subsequent redox homeostasis

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Samudio I, Fiegl M, Konopleva M, Dwyer K, Harmancey R, Guthrie P, Taegtmeyer H, Andreeff M

605 Aldose reductase inhibitor Ranirestat : Ranirestat is a potent aldose reductase inhibitor that reduces nerve sorbitol accumulation