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In AS mouse models, sterile inflammation is also shown to drive cytokine production, and neutrophils, once activated, initiate effector functions and release NETs (120) showed that chloromethyl ketone inhibited PAD4, thereby reducing the formation of NETs and the lesion area of atherosclerotic plaques, further suggesting the important role of NETs in AS

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I have PA and my 15 year old daughter has recently been displaying symptoms - utter exhaustion to the point where she was falling asleep at 4.30pm and sleeping through to the following morning day after day