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Thus, ANKIB1 preferentially generates K11-Ub chains and its catalytic activity facilitates TLR3-induced TBK1 activation, suggesting that ANKIB1-generated K11-Ub may be crucial for TBK1 recruitment and activation upon TLR3 stimulation

Defining the cytosolic pathway of glutathione degradation in Arabidopsis thaliana : role of the ChaC/GCG family of -glutamyl cyclotransferases as glutathione-degrading enzymes and AtLAP1 as the Cys-Gly peptidase

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The study protocol was approved by the medical ethics committee of the Maastricht University Medical Center+, the Netherlands and was in line with the Helsinki Declaration of Human Rights (identifier: NL73600.068.20/METC 20033)