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Again, this likely reflects lower systemic drug exposure rather than a genuine safety advantage of the oral route

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Together, excessive and reduced production of neuro-toxic and -protective kynurenines, respectively, may exacerbate excitotoxicity and neuroinflammation, establishing a feed-forward cycle of KP dysregulation, 5-HT depletion, HPA axis hyperactivity, and increased vulnerability to MDD

However, there remains a significant gap in our understanding of genetic risk factors in other admixed populations, despite the increasing incidence of POAG 75,76 in these diverse communities

Etoh T, Inoguchi T, Kakimoto M, et al