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27,28 PARP members can be categorized into several groups, the poly-ADP-ribosyl transferases (e.g., PARP1, 2, and 5), the mono-ADP-ribosyl transferases (e.g., including PARP 3, 4, 68, and 1016) and RBPs (e.g., PARP7, 10, and 1214)

Pekala, B

APE1 is upregulated in motor neurons of ALS patients compared to age-matched controls (Shaikh and Martin, 2002)

These include interneurons, 5, 6, 7 principal neurons, 8, 9, 10 and astrocytes

Computational drug repurposing, because of the progression in HTC technologies, and omics-based data related to disease indications, are considered as cutting-edge techniques for drug discovery (Emon et al., 2017