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Description

Species differences in the metabolic conjugation of clofibric acid and clofibrate in laboratory animals and man

2000;279(6):L100528

7.2.2.3 Guinea-pig Guinea-pigs (8 of each sex per group) that were administered 385 mg/m 3 (50 ppm) of 1,2-dibromoethane for up to 7 h, 57 times in 80 days, had decreased final body weight and increased lung, liver and kidney weights

Thus, we believe that siRNA escaped from the lysosomes in the form of GNCsiRNA, and the GNCsiRNA was released into the cytoplasm for siRNA-mediated gene silencing