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This highly loaded conjugate demonstrated higher brain uptake than free PTX and significant antitumor activity in vivo in glioblastoma-bearing mice (Rgina et al., 2008)

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First: PI3K/Akt/mTOR, which drives protein synthesis, glucose uptake (via GLUT4 translocation), and anti-apoptotic signaling (particularly relevant in muscle and neuronal tissue)

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