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Data extracted from each study were as follows: the surname of first author, year of publication, country and ethnicity of the subjects, case number and control number with the GSTT1 null, number of total subjects, source of control, genotyping method, and case confirmation approach

Oxidative stress activates multiple transcription factors, including hypoxia-inducible factor-1 (HIF-1), AP-1, NF-B, p53, and nuclear factor erythroid 2-related factor 2 (Nrf2) (Reuter et al., 2010)

While in 1015% X-ALD patients who develop cerebral demyelination spontaneous arrest of demyelinating process occurs with unaltered blood-brain barrier, majority of cALD patients show disrupted blood-brain barrier

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Reh DD, Higgins TS, Smith TL