glutathione peroxidase reaction 2 gsh h2o2 gssg 2h2o Research progress of family (GPX) in redoxidation GSSG Application

What do we do

Gonzalez-Meljem JM, Apps JR, Fraser HC, Martinez-Barbera JP (2018) Paracrine roles of cellular senescence in promoting tumourigenesis

Key enzymes : glucose 6-phosphate dehydrogenase, regulated by the NADP + /NADPH ratio, and transketolase, a thiamine pyrophosphatedependent enzyme

Furthermore, the increased production of H 2 O 2 during RET from glycerol-3-phosphate, proline, or succinate is not due to the glutathionylation of glycerol-3-phosphate dehydrogenase, proline dehydrogenase, or complex II, which donate electrons from these substrates to the UQ pool (Figure 3B)

Indeed, it necessitates the activation of thiolate form of glutathione for direct glutathionylation reaction toward non-conjugated substrates (Dirr et al., 1997)