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The mean height velocity for the group increased from 4.1 +/- 0.9 cm/yr at baseline to 8.0 +/- 1.5 and 7.2 +/- 1.3 cm/yr after 6 and 12 months of therapy, respectively

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This applies even to cancers considered in remission

That does not automatically make it worse, but it does mean the research question is different

Randomisation A randomised and numbered study visit schedule was generated prior to subject recruitment