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Moreover, PPAR agonists activate Dickkopf-1 (DKK1) activity to decrease the canonical WNT/-catenin pathway and then inhibit fibroblast differentiation 122

When GABA neurotransmitters bind with the GABAAR on postsynaptic neurons, that leads to the opening of chlorine channels and, finally, the influx of Cl into the cell, which reduces neuronal excitability by hyperpolarization of the membrane (Ghit et al., 2021)