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A detoxification gene linked to the secretion tag of our construct would theoretically allow the enzyme to be produced and transported out of the cell into the bee gut, which is the principal location of bee insecticide metabolism [1]

Targeted therapy and ototoxicity Newer therapies aimed at specific cancer types, such as tyrosine kinase inhibitors (TKIs), have been associated with vestibular dysfunction, though their precise ototoxic mechanisms remain under investigation

This finding is in line with the improved tolerance achieved by engineering GSH biosynthesis even in the obligate anaerobe Clostridium acetobutylicum against aeration and butanol challenge [67]

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This is a scenario which overstresses the remaining beta cells, which are still capable of providing insulin in the diabetic metabolic state and thus gives rise also to more misfolded proinsulin (Lenzen 2017)