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[DOI] [PMC free article] [PubMed] [Google Scholar] 264.Xu J, Ahmad A, Jones JF, Dolcetti R, Vaccher E, Prasad U, et al

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A significant higher infiltration of immune cells such as macrophages and lymphocytes and pro-inflammatory factors IL-6 and TNF- has been detected in PCOS organ systems, impacting not only the female reproductive system but also other organs such as the cardiovascular, intestine, liver, thyroid, brain and other organs

This potential restoration of p53s function by the FOXO4-DRI peptide might enable it to trigger the programmed cell death of senescent cells, essentially clearing out cells that might otherwise contribute to the decline in tissue function seen in aged cell cultures

They undergo profound chromatin changes, metabolic alterations, cellular remodeling, and resistance to apoptosis (2228)