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It is often called the master antioxidant because it protects every cell against free radicals, recycles other antioxidants, and supports detoxification processes

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358 Abnormal expression of transport proteins/receptors in the BBB, such as downregulation of LRP1 which exports A from the brain to the blood, impaired function of Pgp, and upregulation of RAGE that facilitates the entry of A from the blood into the brain, could be potential reasons for impaired A clearance and substantial accumulation in the brain

Overview of the selenium metabolic system The selenium metabolic system and the biosynthesis of selenoproteins Selenium metabolism is a systemic process that includes the absorption, transportation, transformation, and excretion of selenium (Fig