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Moreover, systemic FGF15 deficiency led to the circadian disturbance of NAD + -dependent SIRT1 signaling and significant reduction of NAD + and SIRT1 activity during nighttime (active phase) in mice, indicating the important implications of FGF15/19 for the circadian regulation of energy homeostasis in response to the feeding/fasting signal

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[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Tsutsumi M, Lasker JM, Shimizu M, Rosman AS, Lieber CS