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doi: 10.1038/jcbfm.2010.23 113 LangstonW.CircuM

In human studies, L-theanine attenuated effects of caffeine on oxygenated hemoglobin, cognition, and mood, suggesting both independent and interactive effects between the two compounds (22)

The dosage chart presented here provides a framework, but the clinical nuances, specifically the titration pace, the dose ceiling, the choice of synergistic agents, and the biomarker monitoring schedule, should be individualized by a physician familiar with both the patient's metabolic history and the evolving evidence base for mitochondrial peptide therapy