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109 The disruption of peripheral immune homeostasis by an imbalanced gut microbiota entering the liver can shape the hepatitis microenvironment, leading to the progression of HBVassociated hepatitis to fibrosis, cirrhosis and eventually HCC

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An increase in FAO causes increases in mitochondrial inner membrane potential and stimulates ROS 50,51 , which further causes oxidative damage of mitochondrial proteins and DNA, making them less efficient in energy metabolism

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