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Desensitization: receptor becomes less responsive when exposed to a high concentration of an agonist drug for a long duration (several minutes)

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sinensis has generated significant breakthroughs in recent years

Moreover, mechanistic studies offer promising pathways, such as neurotrophin signaling, oxidative stress modulation, and inflammatory regulation, but are still primarily grounded in animal models

identified 65 patients, of whom 85% had consanguineous parents, with pathologic ATP8B1 (n = 5), ABCB4 (n = 25), or ABCB11 (n = 35) gene mutations and early-onset cholestatic disease