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Indeed, while efficiently inducing ferroptosis in different tumor cell lines, RSL3 and ML162 were found to also acts on TXRND1, an important detoxifying enzyme whose inhibition can also trigger apoptosis and/or ferroptosis [51, 52]

This technology involves using a high-power laser to induce local PUFA acyl chains in cell or tissue samples, generating lipid peroxidation, and demonstrating the sensitivity of cells or tissues to ferroptosis inducers on-site (257)

High levels of ELOVL5 have been found in mesenchymal-type gastric cancer cells (GCs), where they can increase the generation of arachidonic acid (AA) and adrenic acid (AdA), thus sensitizing tumor cells to ferroptosis [98]

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