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These alterations result in a significantly extended half-lifeup to 120 times longer than native IGF-1due to reduced binding affinity to insulin-like growth factor-binding proteins (IGFBPs)

The modeling of TM16-TM17 allows the identification of putative residues for the stimulated transport of GSH The above results led us to conclude that among the expressed chimeras, M8 is the most significantly affected both for inducing CS and for its GSH-dependent transport activity

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Biopolymer-Liposome hybrid systems for controlled delivery of bioactive compounds: recent advances