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As we age, our bodys ability to create those chemicals naturally declines, so we give it a boost with Hormone Replacement Therapy

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Myoclonus of the cerebral reflex, limb rigidity, alien limb signs, and cortical sensory loss is all symptoms (Riley et al., 1990

Using saccharin as a prototype sweetener at a dose corresponding to the ADI for humans (5 mg/kg per day), the authors further characterised the faecal microbiota composition of saccharin-consuming mice and demonstrated that saccharin induced strong dysbiosis, with an increase in the number of bacteria from the Bacteroides genus and the Clostridiales order

The pharmacokinetic rationale is questionable given the 5-day half-life, but some users report better side effect tolerance with split dosing