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Animal data provides biological plausibility and mechanistic insights but cannot guarantee human efficacy

Immunity 10:3949 Tekeoglu I, Dogan A, Ediz L, Budancamanak M, Demirel A (2007) Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models

Zinc transporter-2 (ZnT2) variants are localized to distinct subcellular compartments and functionally transport zinc

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Heme oxygenase-1 (HO-1), encoded by the HMOX1 gene, is the rate-limiting enzyme in heme catabolism [184]