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These technologies could transform compounds like GHK-Cu, which are effective locally but limited by short systemic half-lives, into practical therapeutic tools

Toxicol Sci 63:5764 Kavian N, Mehlal S, Marut W, Servettaz A, Giessner C, Bourges C, Nicco C, Chreau C, Lemarchal H, Dutilh MF, Cerles O, Guilpain P, Vuiblet V, Chouzenoux S, Galland F, Quere I, Weill B, Naquet P, Batteux F (2016) Imbalance of the vanin-1 pathway in systemic sclerosis

Reduced DHFR activity is relatively uncommon in European populations but considerably more prevalent in some Asian populations

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