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Mol Microbiol 2005

More specifically, Nrf2 activation results in increased production of reduced glutathione (GSH) which is the prominent cellular antioxidant

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While donor biology, including sex, age and ethnicity, had been previously identified as determinants of RBC susceptibility to hemolysis following oxidant insults, 33 by leveraging state of the art metabolomics and lipidomics tools, we report for the first time that these observations could be explained by metabolic factors in the RBC from these donors