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Elevated NNMT activity has emerged as a feature of obesity, metabolic dysfunction, and age-related metabolic decline

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Clinical evidence: A pivotal trial published in the New England Journal of Medicine demonstrated that tesamorelin reduced trunk fat (visceral adipose tissue) by 15 percent compared to placebo over 26 weeks in patients with lipodystrophy (Falutz et al., 2007)

Screening and data extraction Two reviewers (RN and AMR) independently extracted the authors name, study design (parallel or cross-over), year of publication, number of participants, baseline BMI, % female, mean age, intervention and comparator characteristics, duration and the dosage of intervention, dropouts, degree of adherence to the intervention and mean and corresponding sd of change from baseline weight in each study arm