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ClinicalTrials.gov [online], (2015)

Vitamin B12, also known as cobalamin, is a vital nutrient that plays a key role in the production of red blood cells, nerve function, and energy production

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At the same time, it was agreed that symptoms affecting the central nervous system (mental function and neurological function), followed by those affecting the peripheral nervous system, are the most difficult symptoms to link to B12 deficiency (Figure 1), suggesting the need for more specific awareness in a primary medical care setting and an improvement in examination options

Patients rarely wait for randomized trials before acting.