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Int J Mol Sci 21(24):9698 Jhang JJ, Yen GC, Chinese Soc Immunology (2017) The role of Nrf2 in NLRP3 inflammasome activation

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In the context of I/R injury, disruption of tight junction proteins, such as claudins, occludin, and zonula occludens (ZO) proteins, leads to increased BBB permeability (Shi et al., 2016)

With this goal in mind, this review examines the fundamental concepts underlying the development and progression of AMD and re-evaluates the pathogenic pathways associated with the disease, focusing on the impact of injury at the cellular level, with the understanding that critical assessment of the literature may help pave the way to identifying disease-relevant targets

A clinical study confirmed improvements of timed dopaminergic medication on urinary frequency rating scale and increased bladder retention on cystometry in PD patients who scored higher on irritative bladder symptoms [94]