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Carotenoids, particularly -carotenoids, have free radical scavenging characteristics, quenching highly reactive singlet molecular oxygen ( 1 O 2 ) and reducing oxidative damage to cells

This condition, called ochronoisis, is characterized by intensely dark brown, black or slate grey patches on the skin and is very difficult to treat once they develop," he continued

Furthermore, high ROS levels trigger the apoptotic cascade by cleaving caspase 8 (CAS-8) and subsequently activating caspase 3 (CAS-3), which in turn degrades nucleic acids 40

Then, the hydrogels were immersed in PBS (pH 5.5, pH 6.5 or pH 7.4) and incubated at 37 C with gentle shaking

& Karnieli, E