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Acknowledgements Project supported by the National Natural Science Foundation of China (30672748) and Shandong Administration of Traditional Chinese Medicine (2005-070)

In the five in vitro studies, although a decrease in the apoptosis rate of granulosa cells was observed at specific doses, it was not confirmed whether this effect could translate into an improvement in oocyte quality in vivo (Tsui et al., 2017

pulmonary diseases, chronic pain, heart failure, hyperthyroidism, nocturia, gastroesophageal reflux, cancer, pregnancy, pruritus, HIV infection, obstructive sleep apnea syndrome), neurological conditions (i.e