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Irisin activates the SIRT1 signaling pathway to inhibit MPP+-induced SH-SY5Y apoptosis A substantial body of research has confirmed that SIRT1 plays a pivotal role in regulating lactate metabolism and various biological processes involved in mitochondrial antioxidant stress 3 , 8

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While IV therapy is highly effective because it delivers the antioxidant directly into the bloodstream, bypassing the digestive tract entirely, it is also expensive, invasive, and impractical for daily, long-term management

Overall, the study introduces a novel drug delivery strategy and therapeutic framework for psoriasis and related inflammatory dermatoses, offering significant scientific value and translational potential

Kaur P, Miller DR, Andreeff M , Chaganti R, Meyers PA