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Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinsons disease

While HK2 has limited expression in most normal tissues, it is frequently overexpressed in various cancer tissues and has recently been found to be overexpressed in ischemic stroke brain tissues (68, 71, 72)

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Cytokines are released by both damaged epithelial cells and activated resident immune cells, such as macrophages, creating a strong inflammatory milieu within the gut mucosa (113), which is a key driver of apoptosis (114)

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