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Description

Genetic variations in these key enzymes may collectively contribute to elevated estrogen levels in uterine fibroid tissue by enhancing E 2 synthesis and altering the balance of E 2 metabolic pathways [28,29]

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In vitro cytotoxicity assays using SH-SY5Y (human neuroblastoma), Caco-2 (intestinal permeability), and hCMEC/D3 (human brain endothelial) cells demonstrated that nanoencapsulation significantly reduced the inherent cytotoxicity of free coumarin

Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein