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Also, 15-LOX is a key metabolic enzyme in maintaining skin homeostasis

10.1016/j.jsbmb.2019.105496 121

Brach et al., 2009)

Nanoscale 7 (38), 1555315567 (2015)

Butyrate, a major end-product of gut microbes, maintains the intestinal mucosal defense barrier by selectively up-regulating tight junction proteins and regulating energy homeostasis (41)