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We paid attention to LY2090314 (hereafter referred to as LY), an effective and competitive GSK-3/ inhibitor (IC 50 : 1.5 nM/0.9 nM), with little additional non-specific activity against other kinases [29]

Copper is involved in melanin synthesis (hair pigmentation) and is a cofactor for enzymes involved in keratin cross-linking

Additionally, insulin-sensitizing therapies such as pioglitazone, a thiazolidinedione-class antidiabetic agent, have shown promise in reducing A deposition, attenuating neuroinflammation, and suppressing tau hyperphosphorylation (Yarchoan and Arnold 2014)

Other dietary therapies such as the ketogenic diet (KD) have been recognized for their positive effects on disease

Vitamin D helps the immune system make this important distinction, which reduces autoimmune disease formation (25)