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In a cohort study of 14,611 patients (Batra et al., 2021), high levels of IL-6 were shown to be associated with a higher risk of serious adverse cardiovascular events in CKD patients

doi: 10.1289/ehp.1509966

7.2 Immune balance and tolerance: regulatory roles of probiotics 7.2.1 Cytokine reprogramming: anti-inflammatory and tolerogenic pathways Acting as essential molecular messengers, cytokines play a central role in orchestrating immune and inflammatory responses and regulate a wide spectrum of additional physiological processes (243)