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10.1016/j.fct.2013.08.049 71 KaplowitzN.JiC

3.1.1 The role of Se in GD A large number of studies have now confirmed Se deficiency as a risk factor for GD in areas with adequate soil Se levels ( Based on the damage to thyroid cells caused by low Se level, researchers have raised the possibility that Se supplementation may be beneficial in GD and have conducted a series of clinical studies ( Although the current findings are ambiguous and evidence from clinical trials does not favor the use of Se as a routine treatment option in GD, nor does the use of Se supplementation affect the remission and recurrence rates of GD ( 3.1.2 The role of Se in GO Current studies suggest that fibroblasts are distributed in the posterior globular connective tissue and ocular myofilament

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However, the basis for the increased lactate and pyruvate, in some instances, may relate to non-mitochondrial processes such as glycolysis as is suggested by the absence of increased alanine and TCA intermediates noted in some other biomarker clusters (Figure 5, group 4)