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Description

drainage, vol 36

J Clin Pharmacol 38 : 10251034

Our Facility Coming Down: 6 to 24 Hours Serotonin depletion: MDMAs forced serotonin release depletes presynaptic serotonin stores over the course of the high, and as MDMA plasma levels fall below the threshold for clinical effect, serotonin-depleted neurons generate low mood, fatigue, and irritability that define the immediate comedown