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10.1016/S2215-0366(22)00260-7 15

Anemia, diabetes, and chronic kidney disease

At the same time, there was an increasing focus on the potentially harmful effects of lipid peroxidation (Heath and Packer 1968), growing awareness that optimal activities of photosynthetic enzymes required a highly reducing environment (Wolosiuk and Buchanan 1977

In sum, although the study design and interpretation of clinical relevance in the findings of these studies have been debated (157, 158), they have not provided convincing enough evidence of a significant, sustained treatment effect for the Infectious Diseases Society of America (IDSA) to recommend additional antibiotics in their guidelines (159, 160), and the risk of antibiotic resistance at the population level with long-term, untargeted use of antibiotics are often cited as significant concerns (161)

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