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10.1016/s1074-7613(03)00263-2 36

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Biotechnol Adv 54:107795

For instance, the pathogenic V122I variant of the protein transthyretin can induce cardiomyopathy due to destabilization of the transthyretin quaternary structure, i.e., the tetramer-folded monomer equilibrium, and an increased rate of tetramer dissociation [73]