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Disclosures: Kazuma Sekiba: Nothing to Disclose, Bi-Huei Hou: Nothing to Disclose, Haoqing Chen: Nothing to Disclose, Yuanyuan Liu: Nothing to Disclose, Zhiwei Zhou: Nothing to Disclose, Ayana Crawl-Bey: Nothing to Disclose, Dylan Dodd: Nothing to Disclose 1005 LIVER SINUSOIDAL ENDOTHELIAL CELL RESPONSES TO HEPATIC CONGESTION INSTIGATE -CATENIN DEPENDENT PROLIFERATIVE RESPONSES IN PERI-CENTRAL HEPATOCYTES Papawee Sutthirat 1 Nidhi Jalan-Sakrikar 1 Maarouf Hoteit 2 Vijay Shah 1 Moira Hilscher 3 , 1 Mayo Clinic Rochester, 2 University of Pennsylvania, 3 Penn Medicine Background: Liver masses are common in patients with congestive hepatopathy (CH) and may be benign or malignant

In contrast, an mTORC1/SIRT4/GDH/glutamine axis has been identified in cells, and mTORC1 can effectively promote cell proliferation by inhibiting the transcription of SIRT4, a sirtuin located in the mitochondria

Picolinic-acid modulates kainic acid-evoked glutamate release from the striatum in-vitro