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however, after the appearance of prospective randomized studies that indicated an increase in the incidence of breast cancer, the establishment of this therapy has been adjusted to the presence of certain risk factors, symptoms, and the evolution of patients (Davey, 2018

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These transporters are abundantly expressed on the luminal side of endothelial cells in the BBB 120

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On the contrary, the excess of reactive oxygen, nitrogen, and sulfur species and the imbalance of lipids under pathological conditions cause irreversible changes and contribute to oxidative stress leading to cell failure and the development of type 2 diabetes